Weight Loss With Exenatide Treatment

Primary Outcomes

The primary objectives of this study is:

- To investigate possible mechanisms and patterns of weight loss with exenatide treatment, especially among individuals who have robust early weight loss (greater than 5% weight loss in 12 weeks) with exenatide.

Secondary Outcomes

Our secondary objective is to identify metabolic characteristics that predict robust response to exenatide treatment.

Outcome measurements:

Weight
Body composition
Resting energy expenditure (REE)
Mixed meal test
Thermic effect of food
Serum metabolic parameters
Hunger/Nausea/Satiety visual analog scales (VAS)
Physical activity monitoring

Study Population

The study population will be generally healthy, non-diabetic women age 18-70 years with BMI 28-48 kg/m^2.