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Date: 2 August 2021

Peripheral inflammation and microvascular dysfunction are central to the pathophysiology of schizophrenia (SZ). Retinal imaging allows for the accurate quantitative assessment of the condition of retinal microvessels, and early studies implicate microvascular dysfunction in SZ, but the specific

Date: 30 July 2021

A multicenter, randomized, parallel-group, placebo-controlled, double-blind, Phase 1/2a clinical study to investigate the safety, tolerability, immunogenicity and exploratory efficacy of a vaccine regimen consisting of an Ad26.Mos4.HIV prime and a boost with Modified Vaccinia Ankara (MVA)-BN-HIV

Date: 29 July 2021

This is a prospective observational study, the purpose of which is to:

Characterize response of the AV conduction system to TAVR with various prostheses by recording continuous His bundle electrograms during valve placement.
Correlate preprocedure ECG features with changes in AV

Date: 30 April 2021

The purpose of this study is to better understand specific stress-management practices on mood, sleep, and physiology. Participants will be assigned to one of three interventions (they all active interventions - none are a "wait-list"). Each intervention asks participants to engage in a daily

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Date: 14 April 2021

Dr. David Einstein demostrates the use of Alicanto for Virtual Tumor boards on March 5, 2021

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Date: 14 April 2021

These videos demonstrate key features of Alicanto

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Date: 14 April 2021

Presented by Yuri Quintana, PhD and David Einstein, MD at HIMSS New England Conference May 21, 2021

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Date: 14 April 2021

Overview of Alicanto at BIDMC - Presented by Yuri Quintana, PhD and David Einstein, MD, April 14, 2021.

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Date: 8 April 2021

The OPTIMIZE Trial compares whether iDose dashboard-driven infliximab dosing (iDose-driven dosing) is more effective and safer than standard infliximab dosing for inducing and maintaining disease remission in moderately to severely active CD.

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Date: 6 March 2021

See video of this keynote talk.
by Dr. Yuri Quintana Keynote Talk at 10th Annual e-Mental Health Conference, March 4, 2021. This talk will discuss how to integrate research and

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Date: 6 March 2021

by Dr. Yuri Quintana Keynote Talk at 10th Annual e-Mental Health Conference, March 4, 2021. This talk will discuss how to integrate research and practice. It will discuss strategies to evaluate of integrated digital mental health and substance use services, and how to translate evidence into

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Date: 6 January 2021

The main goal of this study is to determine whether there is a relationship between fremanezumab's ability to prevent migraine and improved sleep quality in migraine patients (fremanezumab is a FDA-approved humanized CGRP monoclonal antibody for the treatment of migraine).

This is a

Date: 25 November 2020

The purpose of the study is to determine the optimal surgical approach (ventral vs dorsal) for patients with multi-level cervical spondylotic myelopathy (CSM). There are no established guidelines for the management of patients with CSM, which represents the most common cause of spinal cord

Date: 25 November 2020

The proposed study is a randomized, placebo-controlled clinical trial to test the efficacy of an oral Lactobacillus product dissolved in sterile saline and instilled into the urinary bladder in an attempt to colonize the urinary bladder as well as prevent UTIs.

Date: 25 November 2020

A prospective registry evaluating the efficacy of EC-IC bypass in a subgroup of patients, specifically, patients with carotid occlusion and symptoms refractory to medical therapy and evidence for poor cerebrovascular reserve as evaluated by physiological testing (e.g. Diamox Challenge SPECT Scan

Date: 25 November 2020

The purpose of this study is to determine the effectiveness and adverse effects of 3,4-diaminopyridine for the treatment of the Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenic Syndromes (CMS).

Date: 25 November 2020

Interstitial Lung Abnormalities (ILA) have been previously defined as nondependent changes affecting more than 5% of any lung zone on computed tomography (CT) scans of the lung. Several studies suggest that the prevalence of ILA in participants in non-pulmonary research studies ranges anywhere

Date: 25 November 2020

The purpose of this registry is two fold. First, to determine the comparative effectiveness of decompression alone versus decompression with fusion for patients with degenerative grade I spondylolisthesis and symptomatic lumbar spinal stenosis. Primary analysis will focus on the patients'

Date: 25 November 2020

The purpose of this research study is to determine the safety of CT-011 alone, as well as the combination of the Dendritic cell fusion vaccine and CT-011, after autologous stem cell transplantation (ASCT). We are also trying to find out what effect the combination has on the disease, including

Date: 25 November 2020

Acute myelogenous leukemia (AML) arises from leukemia stem cells that are difficult to eradicate and serve as a reservoir for disease relapse following chemotherapy. A promising area of investigation is the development of immunotherapeutic approaches that stimulate the immune system to recognize